Structural and dynamic features of HLA-B27 subtypes
B. Uchanska-Ziegler*; A. Ziegler; P. Schmieder
Curr. Opin. Rheumatol. 25, 411-418 (2013)
PURPOSE OF REVIEW: The
differential association of HLA-B27 subtypes with ankylosing spondylitis
provides the rationale for a comparative investigation of these proteins.
Results from the last 2 years of research on minimally distinct HLA-B27
subtypes, primarily using biochemical and biophysical techniques, are presented
RECENT FINDINGS: We summarize evidence that micropolymorphisms within the molecules' peptide-binding groove influence wide-ranging biochemical, biophysical and antigenic properties of HLA-B27 molecules, and suggest that distinct, subtype and peptide-dependent dynamics of peptide - heavy chain - ?2-microglobulin heterotrimers could be instrumental for an understanding of the initiation of disease processes that are connected with certain HLA-B27 subtypes.
SUMMARY: The results indicate that mAbs that bind only to structurally distinguishable subsets of HLA-B27 molecules as well as techniques that assess the flexibility of these antigens may hold the key to comprehend molecular events contributing to the initial stages of disease pathogenesis in spondyloarthropathies.